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NO activates guanylate cyclase, which results in increased levels of cGMP, producing smooth muscle relaxation. Need larger quantities for your development, manufacturing or research applications? © 2018  Merck KGaA, Darmstadt, Germany and/or its affiliates. Reproduction of any materials from the site is strictly forbidden without permission. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, Sildenafil is a potent, selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5). Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters From our library of Articles, Sigma-Aldrich presents Pfizer Compounds for Cyclic Nucleotides Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Sildenafil enhances the effect of NO by inhibiting PDE5, which is responsible for degradation of cGMP. Learn more about bioactive small molecules for other areas of research at This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC ), a biologically annotated collection of high-quality, ready-to-screen compounds. To browse other handbook pages, Download BioFiles v7 n5 (3. Mb PDF) Back to Pharmaceutical Drugs and Drug Candidates homepage Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c. Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension.

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